What neurotransmitters does mirtazapine affect

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In this detailed resource, you’ll discover the specific neurotransmitters targeted by mirtazapine, a medication commonly prescribed to treat depression and anxiety disorders.

Unlock the science: Mirtazapine primarily acts on serotonin receptors in the brain, boosting levels of this crucial neurotransmitter to improve mood and alleviate symptoms of depression.

Dive deeper: Learn how mirtazapine affects other neurotransmitters, such as norepinephrine and histamine, to provide a comprehensive understanding of its mechanism of action.

Empower yourself with knowledge and make informed decisions about your mental health with our expert insights on mirtazapine and neurotransmitter modulation. Start your journey to holistic wellness today!

Overview of Mirtazapine

Mirtazapine is a commonly prescribed antidepressant medication that belongs to the class of drugs known as tetracyclic antidepressants. It is primarily used to treat symptoms of depression and anxiety disorders.

How Mirtazapine Works

Mirtazapine works by blocking certain receptors in the brain, including serotonin receptors. By blocking these receptors, mirtazapine increases the levels of serotonin and noradrenaline in the brain, which helps to improve mood and reduce symptoms of depression.

Effects on Neurotransmitters

In addition to affecting serotonin and noradrenaline, mirtazapine also affects other neurotransmitters such as histamine, dopamine, and GABA. These effects help to further enhance the antidepressant properties of mirtazapine.


Serotonin and Noradrenaline are two key neurotransmitters that mirtazapine affects. These neurotransmitters play a crucial role in regulating mood, emotions, and behavior. By influencing the levels of serotonin and noradrenaline in the brain, mirtazapine helps to alleviate symptoms of depression and anxiety.

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Serotonin, also known as the “feel-good” neurotransmitter, is involved in regulating mood, appetite, sleep, and stress. By increasing serotonin levels, mirtazapine can improve mood and reduce feelings of sadness and hopelessness.


Noradrenaline, another neurotransmitter affected by mirtazapine, plays a role in the body’s “fight or flight” response. By modulating noradrenaline levels, mirtazapine can help to reduce feelings of anxiety, fear, and panic.

Neurotransmitter Function
Serotonin Regulates mood, appetite, sleep, and stress
Noradrenaline Involved in the body’s “fight or flight” response

Serotonin and Noradrenaline

When it comes to neurotransmitters, mirtazapine affects serotonin and noradrenaline levels in the brain. These two chemicals are crucial for mood regulation, as they play a significant role in controlling feelings of happiness, anxiety, and overall well-being.

Mirtazapine works by blocking the reuptake of serotonin and noradrenaline, allowing these neurotransmitters to remain in the brain for a longer period. This helps in improving mood and reducing symptoms of depression and anxiety.

By targeting serotonin and noradrenaline, mirtazapine helps to restore the balance of these neurotransmitters in the brain, leading to improved mental health and overall well-being.


Mirtazapine also acts as an antagonist of histamine receptors. Histamine is a neurotransmitter that plays a role in various physiological processes, including regulation of sleep-wake cycles, appetite, and immune responses. By blocking histamine receptors, mirtazapine can cause sedation and weight gain as side effects, which can be beneficial for patients with insomnia or those experiencing weight loss due to depression.

Additionally, the antagonism of histamine receptors by mirtazapine contributes to its antidepressant effects. Histamine is involved in mood regulation, and by modulating histaminergic signaling, mirtazapine can help alleviate symptoms of depression and anxiety.

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Antagonism of Receptors

Mirtazapine also antagonizes certain receptors in the brain, contributing to its mechanism of action. One of the key receptors affected by mirtazapine is the serotonin 5-HT2A receptor, where it acts as an antagonist. By blocking this receptor, mirtazapine can enhance serotonin neurotransmission, which is important for mood regulation and emotional well-being.

In addition to the 5-HT2A receptor, mirtazapine also antagonizes the alpha-2 adrenergic receptors. By blocking these receptors, mirtazapine can increase the release of both serotonin and noradrenaline, leading to an overall improvement in mood and reduction of depressive symptoms.

The antagonistic effects of mirtazapine on these receptors help to regulate neurotransmitter levels in the brain, ultimately contributing to its antidepressant properties.


Dopamine is another key neurotransmitter affected by mirtazapine. Dopamine plays a crucial role in the brain’s reward system, motivation, and movement. By modulating dopamine levels, mirtazapine can help regulate mood and behavior.

Function: Dopamine is involved in feelings of pleasure, reward, and satisfaction. It also helps regulate movement and coordination.
Effects of Mirtazapine: Mirtazapine increases dopamine levels in the brain by blocking specific receptors, leading to improved mood and motivation.
Benefits: By targeting dopamine, mirtazapine can alleviate symptoms of depression, improve motivation, and enhance overall well-being.


GABA, or gamma-aminobutyric acid, is a neurotransmitter that plays a crucial role in regulating neuronal excitability throughout the nervous system. Mirtazapine affects GABA by modulating its release and activity, leading to a decrease in excitatory neurotransmission and an increase in inhibitory signals. This mechanism of action helps to balance brain activity and may contribute to the anxiolytic and sedative effects of mirtazapine.

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