Mirtazapine for severe gastroparesis

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Are you struggling with severe gastroparesis? Mirtazapine may be the solution you’ve been looking for. This medication has shown promising results in managing symptoms of gastroparesis, such as nausea, vomiting, and bloating.

Consult with your healthcare provider to see if Mirtazapine is right for you.

Overview of Gastroparesis

Gastroparesis is a condition that affects the normal movement of muscles in the stomach, resulting in delayed emptying of food into the small intestine. This can lead to symptoms such as nausea, vomiting, bloating, and abdominal pain. Gastroparesis can be caused by various factors, including diabetes, nerve damage, medications, and surgery.

Importance of Treatment: It is important to seek treatment for gastroparesis to manage symptoms and prevent complications such as malnutrition, dehydration, and worsening of the condition. Treatment options may include dietary changes, medications, and in severe cases, surgery.

Stay tuned for more information on effective treatment options for gastroparesis!



Mirtazapine is a medication commonly used for treating severe gastroparesis. It belongs to the class of drugs known as tetracyclic antidepressants. While originally developed for depression, mirtazapine has been found to be effective in managing symptoms of gastroparesis, such as nausea, vomiting, bloating, and abdominal pain.

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Unlike conventional gastroparesis treatments, mirtazapine works by increasing the levels of certain neurotransmitters in the brain, specifically serotonin and norepinephrine. This modulation of neurotransmitter levels helps regulate the contractions of the stomach muscles, improving gastric emptying and reducing symptoms associated with gastroparesis.


Mirtazapine is a medication that is commonly used to treat depression, but it also has benefits for gastroparesis. It belongs to a class of medications known as tetracyclic antidepressants.

Mechanism of Action

Mirtazapine works by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine. This helps to improve communication between the nerves in the stomach and the brain, which can help to alleviate symptoms of gastroparesis.

Mechanism of Action

Mirtazapine is a medication that acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It works by blocking certain receptors in the brain, specifically the α2-adrenergic autoreceptors and heteroreceptors. By blocking these receptors, mirtazapine increases the release of both norepinephrine and serotonin in the brain, leading to an antidepressant effect.

Additionally, mirtazapine has antihistaminic properties, which can help with the symptoms of gastroparesis. By blocking the histamine H1 receptors, mirtazapine can reduce nausea, vomiting, and appetite loss associated with gastroparesis. This mechanism of action makes mirtazapine a promising option for the treatment of severe gastroparesis.

Benefits for Gastroparesis

Patients with gastroparesis can benefit from the use of Mirtazapine as a treatment option. Here are some of the key benefits:

1. Improvement in Symptoms

Mirtazapine has been shown to improve symptoms of gastroparesis such as nausea, vomiting, bloating, and early satiety. Patients may experience relief from these distressing symptoms, leading to an improvement in quality of life.

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2. Enhanced Gastric Emptying

Studies have demonstrated that Mirtazapine can help accelerate gastric emptying in patients with gastroparesis. This can reduce the time food spends in the stomach, decreasing symptoms and improving digestion.

Benefit Description
Improved Quality of Life Mirtazapine can help alleviate symptoms of gastroparesis, leading to an overall improvement in quality of life for patients.
Enhanced Digestion By promoting gastric emptying, Mirtazapine can improve the digestion process and reduce gastrointestinal symptoms.

In summary, Mirtazapine offers several benefits for patients with gastroparesis, including symptom relief, improved gastric emptying, and enhanced quality of life.


It is important to follow the administration instructions provided by your healthcare provider or pharmacist when taking mirtazapine for gastroparesis. The typical dosage regimen involves taking the medication orally, usually once daily at bedtime, with or without food.

Your healthcare provider will determine the appropriate dosage based on your individual condition, response to treatment, and other factors. It is essential to take mirtazapine exactly as prescribed and not to adjust the dosage or stop treatment without consulting your healthcare provider.

Important Administration Tips:

  • Swallow the tablet whole with a glass of water, without crushing, breaking, or chewing it.
  • Do not double up on doses if you miss one. Take the missed dose as soon as you remember, but skip it if it is almost time for your next scheduled dose.
  • Store mirtazapine at room temperature away from moisture and heat.

Dosage and Usage

It is important to follow the prescribed dosage and usage instructions for mirtazapine in the treatment of gastroparesis. The typical starting dose is 15 mg taken orally once daily at bedtime. This dosage may be increased gradually as needed under the guidance of a healthcare provider.

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Dosage Adjustment:

  • If there is no improvement in symptoms after several weeks of treatment, the dosage may be increased up to a maximum of 45 mg per day.
  • For elderly patients or those with liver or kidney impairment, a lower starting dose may be recommended to reduce the risk of side effects.

It is important to take mirtazapine consistently at the same time each day to maintain therapeutic levels in the body. It can be taken with or without food, but it is typically recommended to take it with a meal to minimize the risk of stomach upset.

If a dose is missed, it should be taken as soon as remembered unless it is close to the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule should be resumed.

Patients should not stop taking mirtazapine suddenly without consulting their healthcare provider, as this can lead to withdrawal symptoms. It is important to follow the prescribed dosage and usage instructions for the best therapeutic outcomes.

Side Effects and Precautions

Mirtazapine is generally well-tolerated, but like any medication, it may cause side effects in some individuals. Common side effects of mirtazapine include:

Side Effects Precautions
Drowsiness Avoid driving or operating machinery until you know how mirtazapine affects you
Weight gain Monitor your weight regularly and consult your healthcare provider if you notice significant changes
Dizziness Rise slowly from a sitting or lying position to minimize the risk of dizziness
Constipation Ensure you are drinking enough water and consider adding more fiber to your diet

Other side effects may include:

  • Increased appetite
  • Changes in libido
  • Dry mouth
  • Increased cholesterol levels

It is important to discuss any concerns or unusual side effects with your healthcare provider. Do not stop taking mirtazapine abruptly, as this can lead to withdrawal symptoms. Follow your doctor’s instructions carefully and report any new or worsening symptoms promptly.